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KMID : 1023420150150060794
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Journal of Dental Hygiene Science
2015 Volume.15 No. 6 p.794 ~ p.799
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The Anti-Cancer Effect of β-Gluconsan Calcium on Oral Cancer Cell
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Kim Ji-Hye
Jung Yun-Sook
Kim Hye-Young
Lee Young-Kyun
Kim Jae-Young
Choi Youn-Hee
Song Keun-Bae
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Abstract
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In recent years, there has been a global trend toward the importance of natural extracts for the prevention and treatment of human diseases. β-glucan is known to have anti-inflammatory activity, anti-cancer, and improvement of immune system. Polycan is purified β-glucan from Aureobasidum pullulans SM-2001. The anti-cancer effects of β-gluconsan calcium, polycan and calcium gluconate complex, were evaluated in human oral cancer YD-10B cells. YD-10B cells were cultured in the presence of 0, 0.5, 0.75, 1 mg/ml β-gluconsan calcium for 48 hours. MTT assay, cell counting, and observation of cell morphology were conducted. The number of cells decreased and cell morphology changed in the 0.5 mg/ml of β-gluconsan calcium. Almost all cells were dead in the 0.75 and 1 mg/ml. MTT assay showed a dose-dependent reduction in cell proliferation (p＜0.05). These results indicate that β-gluconsan calcium exhibiting anti-cancer effects in YD-10B cells through changes in cell morphology and cell death.
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KEYWORD
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Anti-cancer, β-gluconsan calcium, Oral cancer cells
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